Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.
The salient pathological feature of Alzheimer disease (AD) is the presence of a high density of amyloid plaques in the brain tissue of victims. The plaques are predominantly composed of human beta-amyloid peptide (beta A4), a 40-mer whose neurotoxicity is related to its aggregation. Radioiodinated human beta A4 is rapidly deposited in vitro from a dilute (less than 10 pM) solution onto neuritic...
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five CQ-treated mice, and two showed no measurable Alzheimer -Amyloid Plaques A in the pellet fraction and no detectable A pathology by immunocytochemistry. The authors then examined the effects of a higher dose (30 mg/kg/d) for 9 weeks in older 21-month-old mice (n ϭ 20) as compared to Transgenic mice developing -amyloid (A) plaques sham-fed mice (n ϭ 19). This resulted in a 41% decrease ...
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Alzheimer's desease is the most common age-related neurodegenerative disorder, and cognitive problems such as defects in learning and memory are of its symptoms. Among the factors involved in the pathogenesis of the disease are biochemical disorders in protein production, oxidative stress, decreased acetylcholine secretion and inflammation of the brain tissue. Extra-neuronal accumulation ...
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The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate with the clinico-pathological dysfunction observed in AD patients. However, the nature (monomeric, dimeric or other oligomers), the relative abundance, and the origin (extra-/i...
متن کاملCharacteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease.
Senile plaques (SPs) containing amyloid β peptide (Aβ) 1-42 are the major species present in Alzheimer disease (AD), whereas Aβ1-40 is the major constituent of arteriolar walls affected by cerebral amyloid angiopathy. The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and c...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2012
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e31825e77de